1,3-Dipolar Cycloaddition to the Fe-N:C Fragment. 14. Aromatic Isothiocyanates as Dipolarophiles. Reversible Formation of Novel [3.2.2] Bicyclic Double Isocyanide Insertion Products. Thermodynamics of Isocyanide Deinsertion Reactions
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چکیده
منابع مشابه
Alkyl and aromatic isocyanide binding to haem complexes.
Equilibrium constants for the binding of ethyl (EIC), n-butyl (BIC), p-toluenesulphonylmethyl (TMIC) and 2,6-dimethylphenyl isocyanides (DIMPI) to an imidazole-haem complex in toluene and aqueous detergent micelle solutions were determined. In contrast to an earlier study, which indicated that the large affinities of myoglobin for binding DIMPI and 2,6-diethylphenylisocyanide (DEPI) relative to...
متن کاملIsocyanide insertion and cyclization reactions to form indolines using pincer-type complexes of scandium.
The addition of 2,6-dimethylphenyl isocyanide (CN[DMeP], two equivalents) to previously reported (PNP)Sc(III) pyridyl complexes resulted in the formation of novel indoline complexes of scandium. By varying the nature of the pyridyl moiety one can intercept an intermediate prior to methyl migration. In addition to structural studies of two indolene complexes, we also propose a mechanism for the ...
متن کامل1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides with Carbonyl Dipolarophiles Yielding Oxazolidine Derivatives.
We provide a comprehensive account of the 1,3-dipolar cycloaddition reactions of azomethine ylides with carbonyl dipolarophiles. Many different azomethine ylides have been studied, including stabilized and non-stabilized ylides. Of the carbonyl dipolarophiles, aldehydes including formaldehyde are the most studied, although there are now examples of cycloadditions with ketones, ketenes and carbo...
متن کاملUnexpected isocyanide-based cascade cycloaddition reaction with methyleneindolinone.
An unprecedented cascade reaction of isocyanide and methyleneindolinone has been established, which represents a novel and different reaction mode. This present transformation involves the ring-opening of methyleneindolinone and the construction of two other new rings simultaneously in an atom-economic manner.
متن کاملIsocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles
Multicomponent reactions (MCRs) are extremely popular owing to their facile execution, high atom-efficiency and the high diversity of products. MCRs can be used to access various heterocycles and highly functionalized scaffolds, and thus have been invaluable tools in total synthesis, drug discovery and bioconjugation. Traditional isocyanide-based MCRs utilize an external nucleophile attacking t...
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ژورنال
عنوان ژورنال: Organometallics
سال: 1994
ISSN: 0276-7333,1520-6041
DOI: 10.1021/om00019a044